Miyoshi Nagayoshi (1522–1564) controlled Awa, Sanuki, Kawachi, and Settsu from Shozui Castle as his base, seizing the real power of the Muromachi shogunate. He expelled shogun Ashikaga Yoshiteru from Kyoto and reigned as the de facto ruler of the Kinai. Under Nagayoshi, Shozui Castle developed from a base for controlling Awa Province to the symbolic headquarters of Kinai supremacy. However, following Nagayoshi's death, the Miyoshi clan rapidly declined. In 1582, Shozui Castle fell to Chosokabe Motochika's invasion, effectively ending the Miyoshi clan.