In 1570, Uesugi Kenshin attacked Matsukura Castle after its lord, Shiina Yasutane, defected to the rival Takeda clan. The castle held out for 100 days, forcing Kenshin to withdraw temporarily, but in 1572 he besieged it again and finally captured it. Thereafter his retainer Kawada Nagachika served as castellan, making Matsukura a key Uesugi stronghold in Etchu.