Yuki Munehiro was the son of Yuki Sukehiro, founder of the Shirakawa-Yuki clan, and its second head. The clan traced its origins to 1189, when the Yuki ancestor Yuki Tomomitsu received the jito post of Shirakawa estate from Minamoto no Yoritomo; Sukehiro is said to have relocated from Shimosa Yuki to Shirakawa Castle around 1289. In 1333, on receiving Emperor Go-Daigo's decree, Munehiro joined Nitta Yoshisada in the assault on Kamakura, contributing to the fall of the Kamakura shogunate. Under the Kenmu Restoration, he was appointed a district magistrate accompanying Kitabatake Akiie's posting as governor of Mutsu, sharing responsibility for the administration of Oshu. In 1336, fighting alongside Akiie in the campaign against Ashikaga Takauji's forces in Kyoto, he distinguished himself and is said to have received the sword "Onimaru" from Emperor Go-Daigo. After Akiie died in battle at Ishizu, Izumi Province in 1338, Munehiro attempted to escort Prince Noriyoshi back to Oshu by sea but was shipwrecked, dying in exile in Ise the following year.

A warrior who remained consistently loyal to Emperor Go-Daigo and Kitabatake Akiie, from the overthrow of the Kamakura shogunate through the administration of Oshu under the Kenmu Restoration.

A monument called "Kanchumei," honoring Munehiro's loyalty, was erected at the Shirakawa Castle site in 1807 and still stands today as a historic marker of the Shirakawa-Yuki clan's legacy.