Born the only daughter of Tamura Kiyoaki, a powerful daimyo of Tamura district in Mutsu Province. Her childhood name 'Megohime' uses the Oshu dialect word 'mego' meaning beloved or dear. Betrothed to Masamune at the age of twelve in 1579 and formally married in 1584, the union was strategically important: the Tamura were a leading daimyo family in southern Oshu, and the marriage helped underpin Date expansion in that direction. While Masamune campaigned across the region, she remained at Sendai Castle (Aoba Castle) managing the inner household and maintaining stability in the domain's internal affairs. When Masamune's late arrival at Odawara incurred Hideyoshi's wrath during the Oshu settlement, she reportedly traveled to Osaka as his envoy and defended her husband boldly before Hideyoshi. She bore multiple children, including Hidemune (later the first lord of Uwajima domain) and Tadamune (later the second lord of Sendai domain). In her later years she adopted the Buddhist name Yokutoku-in and spent her final years peacefully in Sendai, living to the remarkable age of eighty-six.

Intelligent and spirited. She quietly supported Masamune while having the strength to speak out boldly when necessary. Her skill in managing the inner affairs of the Sendai domain as its principal lady is highly regarded.

The temple Yokutoku-in (Taihaku Ward, Sendai) remains as her memorial temple. She is remembered as the wise consort who quietly supported Masamune in building the Sendai domain, living to 86. Her lineage also connected the Tamura domain to the Date clan.