Son of Hosokawa Mochiyuki. Three times Kanrei (deputy shōgun) of the Muromachi shogunate. His feud with Yamana Sōzen over Shōgun Yoshimasa's succession led him to command the Eastern army at the outbreak of the Ōnin War in 1467. He died of illness mid-war, but the eleven-year conflict ushered in the Sengoku age.